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All Cancers/Any Site

  • EAY131 (NCI-MATCH): Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors or Lymphomas
  • ECOG EAQ152: COMET-Communication and Education in Tumor Profiling
  • UW15068: UWCCC Precision Medicine Molecular Tumor Board Registry
  • Strata STR-001-001: An Observational Study Profiling Biospecimens from Cancer Patients to Screen for Molecular Alterations.
  • Exact Science 2018-01: Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors

Breast Cancer


  • Alliance A011502: A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer : The ABC Trial
  • Alliance A211601: Evaluation of Mammographic Breast Density Effect of Aspirin: A Companion Study to Alliance Study A011502
  • NRG BR-003 - A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer


  • NSABP B-51/RTOG 1304: Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
  • SWOG S1418: A Randomized Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with >/1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy.

Metastatic/Advanced Disease:

  • ECOG EAI142: (18F) Fluoroestradiol (FES) PET as a Predictive Measure for Endocrine Therapy in Patients with Newly Diagnosed Metastatic Breast Cancer
  • UW16050 (BTCRC-BRE15-016): A Single Arm Phase II Study of Palbociclib in Combination with Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast Cancer


  • Alliance A011401: Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer

Breast Screening Trials:

  • TMIST: Digital Tomosynthesis Mammography and Digital Mammography in Screening Patients for Breast Cancer

Gastrointestinal Cancer


  • ECOG EA2165: A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer

Biliary Tract:

  • SWOG S1815: A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel vs. Gemcitabine and Cisplatin in Newly Diagnosed Advanced Biliary Tract Cancers. 


  • A021502: Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

  • NRG-GI002: A Phase II Clinical Trial Platform of Sensitization Utilizing Total Neoadjuvant Therapy (TNT) in Rectal Cancer

  • NRG-GI004: Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer

Genitourinary Cancer


  • ECOG-ACRIN EA8143: Multiparametric MRI in Evaluating Cancer Stage and Helping Treatment Planning in Patients With Prostate Cancer


  • ECOG-ACRIN EA8143Phase 3 RandOmized Study Comparing PERioperative Nivolumab Vs. Observation in Patients with Localized Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)


  • City of Hope 96144: Molecular Genetics Studies of Cancer Patients and Their Relatives
  • Genomic Medicine Institute - Cancer Specimen Banking: Molecular Mechanisms Involved in Cancer Predisposition
  • ECOG EAQ152 (COMET) - Communication and Education in Tumor Profiling. A Randomized Study of Pre-Disclosure Genetic Education vs. Usual Care in Tumor Profiling for Advanced Cancer and a Pilot Study of Remote Genetic Counseling for Participants with Potential Germline Mutations Identified on Tumor Profiling. 

Gynecological Cancer:

Ovarian/Fallopian Tube:

  • NRG-GY005: Cediranib Maleate and Olaparib or Standard Chemotherapy in Treating Patients With Recurrent Platinum-Resistant or -Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (COCOS)
  • NRG-GY016: A Phase II Study of MK-3475 (Pembrolizumab) + Epacodastat in Recurrent Clear Cell Carcinoma of the Ovary
  • University of Southern Alabama / MCI GON: A Novel Method of Screening for Ovarian Cancer Using Gynecologic Fluids and Mucus
  • GOG-3015/YO39523 (IMagyn050) - Phase III Randomized Study of Atezolizumab vs. Placebo Administered in Combination with Paclitaxel, Carboplatin, and Bevacizumab to Patients with Newly Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer.

Hematology Cancer:


Acute Myeloid Leukemia (AML):

Chronic Lymphocytic Leukemia (CLL):

  • Alliance A041702: A Randomized Phase III Study of Ibrutinib + Obinutuzumab vs. Ibrutinib + Venetoclax and Obinutuzumab in Untreated Older Patients (>/= 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL) 
  • ECOG-ACRIN EA9161: A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and Obinutuzumab vs. Ibrutinib and Obinutuzumab in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)
  • InformCLL: A Disease Registry for Patients With Chronic Lymphocytic Leukemia

Mantle Cell:

  • PrE0404: A Phase I/II Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma
  • ECOG-ACRIN EA4151: A Randomized Phase III Trial of Consolidation with Autologous Hematopoietic Cell Transplantation Followed by Maintenance Rituximab vs. Maintenance Rituximab Alone for Patients with Mantle Cell Lymphoma in Minimal Residual Disease-Negative First Complete Remission
  • UW16086: Bendamustine + Obinutuzumab Induction Chemoimmunotherapy with Risk-Adapted obinutuzumab Maintenance Therapy in Previously Untreated Mantle Cell lymphoma

Multiple Myeloma:

  • ECOG E1A11: Randomized Phase III Trial of Bortezomib, Lenalidomide and Dexamethasone (VRd) Versus Carfilzomib, Lenalidomide, Dexamethasone (CRd) Followed by Limited or Indefinite Lenalidomide Maintenance in Patients With Newly Diagnosed Symptomatic Multiple Myeloma
  • Alliance A061202: A Phase I/II Study of Pomalidomide, Dexamethasone, and Ixazomib vs. Pomalidomide and Dexamethasone for Patients with Multiple Myeloma Refractory to Lenalidomide and Proteasome Inhibitor-Based Therapy.

Myelodysplastic Syndrome (MDS)/Anemia:

  • ConnectMDS/AML: The Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Registry
  • AZA-MDS-003: Phase III Randomized, Double-Blind Study to Compare the Efficacy and Safety of Oral Azacitidine + Best Supportive Care vs. Placebo + Best Supportive Care in Subjects with Red Blood Cell Transfusion-Dependent Anemia and Thrombocytopenia Due to IPSS Lower-Risk Myelodysplastic Syndromes


  • Exact Science 2018-02: Blood Sample Collection to Evaluate Biomarkers in Subjects with Untreated Hematologic Malignancies

Lung Cancer

Non-Small Cell Lung Cancer (NSCLC):

  • Alliance A081105: Erlotinib Hydrochloride in Treating Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been Completely Removed by Surgery (An ALCHEMIST Treatment Trial)
  • Alliance A151216: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery
  • ECOG E4512: Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)
  • ECOG EA5142: Adjuvant Nivolumab in Resected Cancers (ANVIL) A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung Cancers
  • Cypress 1: An Open Label Randomized Phase II Trial of AM0010 in Combination with Pembrolizumab vs. Pembrolizumab Alone as First-Line Therapy in Patients with Stage IV/Metastatic Non-Small Cell Lung Cancer and Tumors with High Expression of PD-L1 (>/= 50%)
  • S1900 (LUNGMAP): A Master Protocol to Evaluate Biomarker Driven Therapies and Immunotherapies in Previously Treated Non-Small Cell Lung Cancer (Lung-Map Screening Study)


  • Exact Science 2016-11: Blood Sample Collection in Subjects Participating in Lung Cancer Screening Program

Skin Cancer

  • ECOG EA6141: Randomized Phase II/III Study of Nivolumab plus Ipilumumab plus Sargramstim versus Nivolumab plus Ipilumumab in Patients with Unresectable Stage III or Stage IV Melanoma.
  • SWOG S1320: A Randomized, Phase II Trial of INtermittent vs. Continuous Dosing of Dabrafenib and Trametinib in BRAF Mutant Melanoma
  • SWOG S1801: A Phase II Randomized Study of Adjuvant vs Neo-Adjuvant MK-3475 (Pembrolizumab) for Clinically Detectable Stage III-IV High-Risk Melanoma


  • Exact Science 2018-03: Blood Sample Collection to Evaluate Biomarkers in Subjects with Untreated Melanoma

Neurological/Brain Cancer

Glioblastoma Multiforme (GBM):

  • ECOG EAF151: Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma.

Low Grade Glioma:

  • NCCTG N0577: Phase III Intergroup Study of Temozolomide Alone versus Radiotherapy with Concomitant and Adjuvant Temozolomide Versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma


  • Alliance A071401- Phase II Trial of SMO/AKT/NF2 Inhibitors in Progressive Meningiomas with SMO/AKT/NF2 Mutations
  • NRG-BN003 - Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

Symptom Management:

  • EAP-001: An Open-Label, Expanded Access Protocol for Firdapse Treatment in Patients with Lambert-Eaton Myasthenic Syndrome (LEMS), Congenital Myasthenic Syndromes (CMS) and Downbeat Nystagmus.


  • Alliance A021602: Randomized, Double-Blinded Phase III Study of Cabozantinib vs. Placebo in Patients with Advanced Neuroendocrine Tumors After Progression on Everolimus (CABINET)